Research
Patrick McNutt is an associate professor at the Wake Forest Institute for Regenerative Medicine. Patrick does research in Neuroscience, Molecular Biology and Cell Biology.
Highlighted
Aminopyridines Restore Ventilation and Reverse Respiratory Acidosis at Late Stages of Botulism in Mice.
The Journal of pharmacology and experimental therapeutics
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17 Jan 2024
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pubmed:37977816
A study on the effects of aminopyridines, particularly 3,4-diaminopyridine (3,4-DAP), on ventilation and respiration in botulism reveals significant improvements in respiratory function and acid-base balance, suggesting potential as a therapeutic option and laying groundwork for further development of aminopyridine derivatives.
Antidotal treatment of botulism in rats by continuous infusion with 3,4-diaminopyridine.
Molecular medicine (Cambridge, Mass.)
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03 Jun 2022
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pubmed:35659174
The molecule 3,4-DAP is the first small molecule to reverse systemic paralysis and promote survival in animal models of botulism, thereby meeting a critical treatment need that is not addressed by post-exposure prophylaxis with conventional antitoxin.
Dose-dependent emergence of acute and recurrent corneal lesions in sulfur mustard-exposed rabbit eyes.
Toxicology letters
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23 Jan 2021
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pubmed:33497768
These results provide novel insight into long-term corneal pathophysiological responses to acute toxicity and identify exposure conditions suitable for therapeutic testing.
All
2024
Exploring the host response in infected lung organoids using NanoString technology: A statistical analysis of gene expression data.
PloS one
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26 Nov 2024
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pubmed:39591472
The Degradation of Botulinum Neurotoxin Light Chains Using PROTACs.
International journal of molecular sciences
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08 Jul 2024
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pubmed:39000579
A comparative analysis of RNA-Seq and NanoString technologies in deciphering viral infection response in upper airway lung organoids.
Frontiers in genetics
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18 Jun 2024
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pubmed:38957806
Analysis of gene expression dynamics and differential expression in viral infections using generalized linear models and quasi-likelihood methods.
Frontiers in microbiology
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09 Apr 2024
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pubmed:38655085
Aminopyridines Restore Ventilation and Reverse Respiratory Acidosis at Late Stages of Botulism in Mice.
The Journal of pharmacology and experimental therapeutics
·
17 Jan 2024
·
pubmed:37977816
A study on the effects of aminopyridines, particularly 3,4-diaminopyridine (3,4-DAP), on ventilation and respiration in botulism reveals significant improvements in respiratory function and acid-base balance, suggesting potential as a therapeutic option and laying groundwork for further development of aminopyridine derivatives.
Insights into optimizing exosome therapies for acute skin wound healing and other tissue repair.
Frontiers of medicine
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13 Jan 2024
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pubmed:38216854
2023
Neuromuscular recovery from botulism involves multiple forms of compensatory plasticity.
Frontiers in cellular neuroscience
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15 Aug 2023
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pubmed:37650071
Therapeutic Benefits of Stem Cells and Exosomes for Sulfur-Mustard-Induced Tissue Damage.
International journal of molecular sciences
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09 Jun 2023
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pubmed:37373093
2022
Editorial: Venoms, animal and microbial toxins, volume II.
Frontiers in pharmacology
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19 Aug 2022
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pubmed:36059944
Urine-Derived Stem Cells for Epithelial Tissues Reconstruction and Wound Healing.
Pharmaceutics
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11 Aug 2022
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pubmed:36015295
Intramuscular delivery of formulated RNA encoding six linked nanobodies is highly protective for exposures to three Botulinum neurotoxin serotypes.
Scientific reports
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08 Jul 2022
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pubmed:35803998
Antidotal treatment of botulism in rats by continuous infusion with 3,4-diaminopyridine.
Molecular medicine (Cambridge, Mass.)
·
03 Jun 2022
·
pubmed:35659174
The molecule 3,4-DAP is the first small molecule to reverse systemic paralysis and promote survival in animal models of botulism, thereby meeting a critical treatment need that is not addressed by post-exposure prophylaxis with conventional antitoxin.
2021
Editorial: Venoms, Animal and Microbial Toxins.
Frontiers in pharmacology
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26 May 2021
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pubmed:34122121
Dose-dependent emergence of acute and recurrent corneal lesions in sulfur mustard-exposed rabbit eyes.
Toxicology letters
·
23 Jan 2021
·
pubmed:33497768
These results provide novel insight into long-term corneal pathophysiological responses to acute toxicity and identify exposure conditions suitable for therapeutic testing.
Neuronal delivery of antibodies has therapeutic effects in animal models of botulism.
Science translational medicine
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06 Jan 2021
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pubmed:33408188
2020
Special Delivery: Potential Mechanisms of Botulinum Neurotoxin Uptake and Trafficking within Motor Nerve Terminals.
International journal of molecular sciences
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18 Nov 2020
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pubmed:33218099
The Need for Improved Therapeutic Approaches to Protect the Cornea Against Chemotoxic Injuries.
Translational vision science & technology
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02 Nov 2020
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pubmed:33200044
Camelid VHH Antibodies that Neutralize Botulinum Neurotoxin Serotype E Intoxication or Protease Function.
Toxins
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24 Sep 2020
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pubmed:32987745
Functional basis for dose-dependent antagonism of rat and rabbit neuromuscular transmission by the bis-pyridinium oxime MMB4.
Archives of toxicology
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20 Jul 2020
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pubmed:32691075
Corneal Endothelial Cell Toxicity Determines Long-Term Outcome After Ocular Exposure to Sulfur Mustard Vapor.
Cornea
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01 May 2020
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pubmed:32044824
Characterization and treatment of spontaneous recurrent seizures following nerve agent-induced status epilepticus in mice.
Epilepsy research
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10 Mar 2020
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pubmed:32182542
Structural Insights into Rational Design of Single-Domain Antibody-Based Antitoxins against Botulinum Neurotoxins.
Cell reports
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25 Feb 2020
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pubmed:32101733
2019
Retrograde activation of CB1R by muscarinic receptors protects against central organophosphorus toxicity.
Neuropharmacology
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24 May 2019
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pubmed:31132436
2018
Photocatalytic Oxidation of Sulfur Mustard and Its Simulant on BODIPY-Incorporated Polymer Coatings and Fabrics.
ACS applied materials & interfaces
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25 May 2018
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pubmed:29766717
3,4-diaminopyridine reverses paralysis in botulinum neurotoxin-intoxicated diaphragms through two functionally distinct mechanisms.
Toxicology and applied pharmacology
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30 Jan 2018
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pubmed:29366638
2017
Use-dependent potentiation of voltage-gated calcium channels rescues neurotransmission in nerve terminals intoxicated by botulinum neurotoxin serotype A.
Scientific reports
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20 Nov 2017
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pubmed:29158500
In vitro and ex vivo screening of candidate therapeutics to restore neurotransmission in nerve terminals intoxicated by botulinum neurotoxin serotype A1.
Toxicon : official journal of the International Society on Toxinology
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17 Oct 2017
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pubmed:29054436
Engineering Botulinum Neurotoxin C1 as a Molecular Vehicle for Intra-Neuronal Drug Delivery.
Scientific reports
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21 Feb 2017
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pubmed:28220863
2016
Contributions of tissue-specific pathologies to corneal injuries following exposure to SM vapor.
Annals of the New York Academy of Sciences
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16 Jun 2016
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pubmed:27310673
2015
Botulinum and Tetanus Neurotoxin-Induced Blockade of Synaptic Transmission in Networked Cultures of Human and Rodent Neurons.
Toxicological sciences : an official journal of the Society of Toxicology
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28 Nov 2015
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pubmed:26615023
Importance of being Nernst: Synaptic activity and functional relevance in stem cell-derived neurons.
World journal of stem cells
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26 Jul 2015
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pubmed:26240679
Accelerated intoxication of GABAergic synapses by botulinum neurotoxin A disinhibits stem cell-derived neuron networks prior to network silencing.
Frontiers in cellular neuroscience
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23 Apr 2015
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pubmed:25954159
2014
Cultivation and characterization of limbal epithelial stem cells on contact lenses with a feeder layer: toward the treatment of limbal stem cell deficiency.
Cornea
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01 Jan 2014
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pubmed:24162749
2013
Novel application of stem cell-derived neurons to evaluate the time- and dose-dependent progression of excitotoxic injury.
PloS one
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14 May 2013
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pubmed:23691214
Morphological and functional differentiation in BE(2)-M17 human neuroblastoma cells by treatment with Trans-retinoic acid.
BMC neuroscience
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18 Apr 2013
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pubmed:23597229
Longitudinal RNA sequencing of the deep transcriptome during neurogenesis of cortical glutamatergic neurons from murine ESCs.
F1000Research
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07 Feb 2013
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pubmed:24358889
2012
High yield derivation of enriched glutamatergic neurons from suspension-cultured mouse ESCs for neurotoxicology research.
BMC neuroscience
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24 Oct 2012
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pubmed:23095170
Compatibility of SYTO 13 and Hoechst 33342 for longitudinal imaging of neuron viability and cell death.
BMC research notes
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14 Aug 2012
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pubmed:22892216
2006
Characterization of the 16S-23S internal transcribed spacer among 34 higher plants: suitability for interspecific plastid transformation.
Plant cell reports
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16 Aug 2006
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pubmed:16912867
Intestinal fatty acid binding protein (I-FABP) for the detection of strangulated mechanical small bowel obstruction.
Current surgery
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01 Jan 2006
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pubmed:16971202
1999
Cadherins and their connections: adhesion junctions have broader functions.
Current opinion in cell biology
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01 Oct 1999
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pubmed:10508659